Published every 5 years after extensive global resuscitation science review and consensus, the 2025 AHA Guidelines for CPR and ECC forms the basis of all the AHA lifesaving products and many lifesaving protocols in hospitals and emergency response services around the world. This cornerstone product is the AHA’s reprint of the 2025 AHA Guidelines for CPR and ECC, which published online in Circulation. Updated guidelines reflect new global resuscitation science and treatment recommendations derived from the 2025 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care with Treatment Recommendations (CoSTR).